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Glutaric Acid-Mediated Apoptosis in Primary Striatal Neurons
Joint Authors
Fu, Xi
Liang, Yan
Tian, Fengyan
Ning, Qin
Ying, Yanqin
Hou, Ling
Luo, Xiaoping
Gao, Jinzhi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Glutaric acid (GA) has been implicated in the mechanism of neurodegeneration in glutaric aciduria type I.
In the present study, the potential cytotoxic effects of GA (0.1~50 mM for 24~96 h) were examined in cultured primary rat striatal neurons.
Results showed increase in the number of cells labeled by annexin-V or with apoptotic features shown by Hoechst/PI staining and transmission electron microscopy (TEM) and upregulation of the expression of mRNA as well as the active protein fragments caspase 3, suggesting involvement of the caspase 3-dependent apoptotic pathway in GA-induced striatal neuronal death.
This effect was in part suppressed by the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 but not the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) antagonist 6-cyano-7-nitroquinoxalone-2,3-dione (CNQX).
Thus, GA may trigger neuronal damage partially through apoptotic pathway and via activation of NMDA receptors in cultured primary striatal neurons.
American Psychological Association (APA)
Tian, Fengyan& Fu, Xi& Gao, Jinzhi& Ying, Yanqin& Hou, Ling& Liang, Yan…[et al.]. 2014. Glutaric Acid-Mediated Apoptosis in Primary Striatal Neurons. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-475320
Modern Language Association (MLA)
Tian, Fengyan…[et al.]. Glutaric Acid-Mediated Apoptosis in Primary Striatal Neurons. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-475320
American Medical Association (AMA)
Tian, Fengyan& Fu, Xi& Gao, Jinzhi& Ying, Yanqin& Hou, Ling& Liang, Yan…[et al.]. Glutaric Acid-Mediated Apoptosis in Primary Striatal Neurons. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-475320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475320