Inhibition of Experimental Autoimmune Encephalomyelitis in Human C-Reactive Protein Transgenic Mice Is FcγRIIB Dependent

Joint Authors

Jones, Nicholas R.
Hu, Xian-Zhen
Ramos, Theresa N.
McCrory, Mark A.
Szalai, Alexander J.
Skibinski, Gregory A.
Wright, Tyler T.
Barnum, Scott R.

Source

Autoimmune Diseases

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-10-12

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Diseases

Abstract EN

We showed earlier that experimental autoimmune encephalomyelitis (EAE) in human C-reactive protein (CRP) transgenic mice (CRPtg) has delayed onset and reduced severity compared to wild-type mice.

Since human CRP is known to engage Fc receptors and Fc receptors are known to play a role in EAE in the mouse, we sought to determine if FcγRI, FcγRIIb, or FcγRIII was needed to manifest human CRP-mediated protection of CRPtg.

We report here that in CRPtg lacking either of the two activating receptors, FcγRI and FcγRIII, the beneficial effects of human CRP are still observed.

In contrast, if CRPtg lack expression of the inhibitory receptor FcγRIIB, then the beneficial effect of human CRP is abrogated.

Also, subcutaneous administration of purified human CRP stalled progression of ongoing EAE in wild-type mice, but similar treatment failed to impede EAE progression in mice lacking FcγRIIB.

The results reveal that a CRP→FcγRIIB axis is responsible for protection against EAE in the CRPtg model.

American Psychological Association (APA)

Hu, Xian-Zhen& Wright, Tyler T.& Jones, Nicholas R.& Ramos, Theresa N.& Skibinski, Gregory A.& McCrory, Mark A.…[et al.]. 2010. Inhibition of Experimental Autoimmune Encephalomyelitis in Human C-Reactive Protein Transgenic Mice Is FcγRIIB Dependent. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-475332

Modern Language Association (MLA)

Hu, Xian-Zhen…[et al.]. Inhibition of Experimental Autoimmune Encephalomyelitis in Human C-Reactive Protein Transgenic Mice Is FcγRIIB Dependent. Autoimmune Diseases No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-475332

American Medical Association (AMA)

Hu, Xian-Zhen& Wright, Tyler T.& Jones, Nicholas R.& Ramos, Theresa N.& Skibinski, Gregory A.& McCrory, Mark A.…[et al.]. Inhibition of Experimental Autoimmune Encephalomyelitis in Human C-Reactive Protein Transgenic Mice Is FcγRIIB Dependent. Autoimmune Diseases. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-475332

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-475332