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Endocytosis and Recycling of Tight Junction Proteins in Inflammation
Joint Authors
Mennigen, Rudolf
Utech, Markus
Bruewer, Matthias
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A critical function of the epithelial lining is to form a barrier that separates luminal contents from the underlying interstitium.
This barrier function is primarily regulated by the apical junctional complex (AJC) consisting of tight junctions (TJs) and adherens junctions (AJs) and is compromised under inflammatory conditions.
In intestinal epithelial cells, proinflammatory cytokines, for example, interferon-gamma (IFN-γ), induce internalization of TJ proteins by endocytosis.
Endocytosed TJ proteins are passed into early and recycling endosomes, suggesting the involvement of recycling of internalized TJ proteins.
This review summarizes mechanisms by which TJ proteins under inflammatory conditions are internalized in intestinal epithelial cells and point out comparable mechanism in nonintestinal epithelial cells.
American Psychological Association (APA)
Utech, Markus& Mennigen, Rudolf& Bruewer, Matthias. 2009. Endocytosis and Recycling of Tight Junction Proteins in Inflammation. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-475335
Modern Language Association (MLA)
Utech, Markus…[et al.]. Endocytosis and Recycling of Tight Junction Proteins in Inflammation. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-475335
American Medical Association (AMA)
Utech, Markus& Mennigen, Rudolf& Bruewer, Matthias. Endocytosis and Recycling of Tight Junction Proteins in Inflammation. Journal of Biomedicine and Biotechnology. 2009. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-475335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475335