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Early Life Factors and Type 2 Diabetes Mellitus
Joint Authors
Wang, Yan
Jiang, Xinli
Ma, Huijie
Liu, Yan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Type 2 diabetes mellitus (T2DM) is a multifactorial disease, and its aetiology involves a complex interplay between genetic, epigenetic, and environmental factors.
In recent years, evidences from both human and animal experiments have correlated early life factors with programming diabetes risk in adult life.
Fetal and neonatal period is crucial for organ development.
Many maternal factors during pregnancy may increase the risk of diabetes of offsprings in later life, which include malnutrition, healthy (hyperglycemia and obesity), behavior (smoking, drinking, and junk food diet), hormone administration, and even stress.
In neonates, catch-up growth, lactation, glucocorticoids administration, and stress have all been found to increase the risk of insulin resistance or T2DM.
Unfavorable environments (socioeconomic situation and famine) or obesity also has long-term negative effects on children by causing increased susceptibility to T2DM in adults.
We also address the potential mechanisms that may underlie the developmental programming of T2DM.
Therefore, it might be possible to prevent or delay the risk for T2DM by improving pre- and/or postnatal factors.
American Psychological Association (APA)
Jiang, Xinli& Ma, Huijie& Wang, Yan& Liu, Yan. 2013. Early Life Factors and Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-475349
Modern Language Association (MLA)
Jiang, Xinli…[et al.]. Early Life Factors and Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-475349
American Medical Association (AMA)
Jiang, Xinli& Ma, Huijie& Wang, Yan& Liu, Yan. Early Life Factors and Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-475349
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475349