CD73-Generated Adenosine : Orchestrating the Tumor-Stroma Interplay to Promote Cancer Growth
Joint Authors
Turcotte, Martin
Allard, Bertrand
Stagg, John
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Despite the coming of age of cancer immunotherapy, clinical benefits are still modest.
An important barrier to successful cancer immunotherapy is that tumors employ a number of mechanisms to facilitate immune escape, including the production of anti-inflammatory cytokines, the recruitment of regulatory immune subsets, and the production of immunosuppressive metabolites.
Significant therapeutic opportunity exists in targeting these immunosuppressive pathways.
One such immunosuppressive pathway is the production of extracellular adenosine by CD73, an ectonucleotidase overexpressed in various types of cancer.
We hereafter review the biology of CD73 and its role in cancer progression and metastasis.
We describe the role of extracellular adenosine in promoting tumor growth through paracrine and autocrine action on tumor cells, endothelial cells, and immune cells.
American Psychological Association (APA)
Allard, Bertrand& Turcotte, Martin& Stagg, John. 2012. CD73-Generated Adenosine : Orchestrating the Tumor-Stroma Interplay to Promote Cancer Growth. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-475352
Modern Language Association (MLA)
Allard, Bertrand…[et al.]. CD73-Generated Adenosine : Orchestrating the Tumor-Stroma Interplay to Promote Cancer Growth. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-475352
American Medical Association (AMA)
Allard, Bertrand& Turcotte, Martin& Stagg, John. CD73-Generated Adenosine : Orchestrating the Tumor-Stroma Interplay to Promote Cancer Growth. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-475352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475352