Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic Features
Joint Authors
Bertucci, François
Chetaille, Bruno
Xerri, Luc
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gene expression profiling studies based on DNA microarrays have demonstrated their ability to define the interaction pathways between neoplastic and nonmalignant stromal cells in cancer tissues.
During the past ten years, a number of approaches including microdissection have tried to resolve the variability in DNA microarray measurements stemming from cancer tissue sample heterogeneity.
Another approach, designated as virtual or in silico microdissection, avoids the laborious and time-consuming step of anatomic microdissection.
It consists of confronting the gene expression profiles of complex tissue samples to those of cell lines representative of different cell lineages, different differentiation stages, or different signaling pathways.
This strategy has been used in recent studies aiming to analyze microenvironment alterations using gene expression profiling of nonmicrodissected classical Hodgkin lymphoma tissues in order to generate new prognostic factors.
These recent contributions are detailed and discussed in the present paper.
American Psychological Association (APA)
Bertucci, François& Chetaille, Bruno& Xerri, Luc. 2010. Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic Features. Advances in Hematology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-475372
Modern Language Association (MLA)
Bertucci, François…[et al.]. Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic Features. Advances in Hematology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-475372
American Medical Association (AMA)
Bertucci, François& Chetaille, Bruno& Xerri, Luc. Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic Features. Advances in Hematology. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-475372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475372