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Ameliorate Effects of Li-Fu Formula on IL-6-Mediated Cardiac Hypertrophy in Hamsters Fed with a Hyper-Cholesterol Diet
Joint Authors
Tsai, Fuu-Jen
Wu, Chieh-His
Hsu, Tsai-Ching
Wang, Hsueh-Fang
Kuo, Wei-Wen
Tsai, Chang-Hai
Tzang, Bor-Show
Lin, James A.
Cheng, Yi-Chang
Huang, Chih-Yang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hypercholesterolemia diets are considered as major sources to cause cardiac hypertrophy.
This study intends to evaluate the effects of Li-Fu formula on cardiac hypertrophy induced by hypercholesterolemia diet.
Twenty-four male Golden Syrian hamsters were randomly divided into control, cholesterol and Li-Fu formula groups and fed with different experimental diets for 2 months.
Histopathological analysis and western blotting were performed to measure the myocardial architecture, and various cardiac hypertrophy-associated molecules in the excised left ventricle from hamsters.
The ratios of whole heart weight/body weight (BW) and left ventricle weight/BW were significantly higher in the cholesterol group but significantly lower in the Li-Fu formula group.
The protein levels of both atrial natriuretic peptide and brain natriuretic peptide were significantly increased in the cholesterol group but significantly reduced in the Li-Fu formula group.
Additionally, significantly increased interleukin-6, STAT3, MEK5, p-ERK5 and non-cardiomyocyte proliferate signal molecules such as p-MEK and p-ERK, were detected in the cholesterol group but significantly reduced in the Li-Fu formula group.
Notably, no significant variations of inflammatory signaling molecules, including p-P38 and p-JNK, were detected in all groups.
Our experimental results demonstrated the significant reductions of cardiac hypertrophy and related eccentric hypertrophy signaling, non-cardiomyocyte proliferate signaling in the excised left ventricle of hamsters from the Li-Fu formula.
We suggested the protective effects of Li-Fu formula on cardiac hypertrophy that may be useful in prevention or treatment of hypertrophy-associated cardiovascular diseases.
American Psychological Association (APA)
Cheng, Yi-Chang& Wu, Chieh-His& Kuo, Wei-Wen& Lin, James A.& Wang, Hsueh-Fang& Tsai, Fuu-Jen…[et al.]. 2011. Ameliorate Effects of Li-Fu Formula on IL-6-Mediated Cardiac Hypertrophy in Hamsters Fed with a Hyper-Cholesterol Diet. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-475389
Modern Language Association (MLA)
Cheng, Yi-Chang…[et al.]. Ameliorate Effects of Li-Fu Formula on IL-6-Mediated Cardiac Hypertrophy in Hamsters Fed with a Hyper-Cholesterol Diet. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-475389
American Medical Association (AMA)
Cheng, Yi-Chang& Wu, Chieh-His& Kuo, Wei-Wen& Lin, James A.& Wang, Hsueh-Fang& Tsai, Fuu-Jen…[et al.]. Ameliorate Effects of Li-Fu Formula on IL-6-Mediated Cardiac Hypertrophy in Hamsters Fed with a Hyper-Cholesterol Diet. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-475389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475389