Iron Metabolism Disturbance in a French Cohort of ALS Patients
Joint Authors
Moreau, Caroline
Devos, David
Vourc’h, Patrick
Benzimra, Simon
Blasco, Hélène
Mucha, Aleksandra
Mallet, Cindy
Andres, Christian R.
Veyrat-Durebex, Charlotte
Corcia, Philippe
Gendrot, Chantal
Maillot, François
Pagès, Jean-Christophe
Piver, Eric
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
The aim of this study was to assess iron status in a cohort of amyotrophic lateral sclerosis (ALS) patients compared to controls in order to evaluate these parameters as a risk factor or a modifying factor of ALS.
Methods.
We collected serum iron, ferritin, transferrin, total iron-binding capacity, and transferrin saturation coefficient (TSC) from 104 ALS patients at the time of diagnosis and from 145 controls.
We reported phenotypic characteristics and evolution parameters such as ALSFRS-R and forced vital capacity at diagnosis and after one year of follow-up.
In a first step we compared iron status between ALS patients and controls, and then we evaluated the relation between iron status and disease evolution of ALS patients using univariate and multivariate analysis.
Results.
We observed increased concentrations of serum iron (P=0.002) and ferritin (P<0.0001) and increased TSC (P=0.017) in ALS patients.
We also showed an association between markers of iron status and high body weight loss in ALS patients.
The multivariate analysis of survival highlighted a significant relation between ferritin level and disease duration (P=0.038).
Conclusion.
This is the first study showing a higher concentration of serum iron in ALS patients, strengthening the involvement of a deregulation of iron metabolism in ALS.
American Psychological Association (APA)
Veyrat-Durebex, Charlotte& Corcia, Philippe& Mucha, Aleksandra& Benzimra, Simon& Mallet, Cindy& Gendrot, Chantal…[et al.]. 2014. Iron Metabolism Disturbance in a French Cohort of ALS Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-475405
Modern Language Association (MLA)
Veyrat-Durebex, Charlotte…[et al.]. Iron Metabolism Disturbance in a French Cohort of ALS Patients. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-475405
American Medical Association (AMA)
Veyrat-Durebex, Charlotte& Corcia, Philippe& Mucha, Aleksandra& Benzimra, Simon& Mallet, Cindy& Gendrot, Chantal…[et al.]. Iron Metabolism Disturbance in a French Cohort of ALS Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-475405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475405