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Lactococcus lactis NCC 2287 Alleviates Food Allergic Manifestations in Sensitized Mice by Reducing IL-13 Expression Specifically in the Ileum
Joint Authors
Prioult, Guénolée
Moingeon, Philippe
Weiss, Marietta
Moussu, Hélène
Zuercher, Adrian W.
Moser, Mireille
van Overtvelt, Laurence
Mercenier, Annick
Nutten, Sophie
Singh, Anurag
Horiot, Stéphane
Holvoet, Sébastien
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
Utilizing a food allergy murine model, we have investigated the intrinsic antiallergic potential of the Lactococcus lactis NCC 2287 strain.
Methods.
BALB/c mice were sensitized at weekly intervals with ovalbumin (OVA) plus cholera toxin (CT) by the oral route for 7 weeks.
In this model, an oral challenge with a high dose of OVA at the end of the sensitization period leads to clinical symptoms.
Lactococcus lactis NCC 2287 was given to mice via the drinking water during sensitization (prevention phase) or after sensitization (management phase).
Results.
Lactococcus lactis NCC 2287 administration to sensitized mice strikingly reduced allergic manifestations in the management phase upon challenge, when compared to control mice.
No preventive effect was observed with the strain.
Lactococcus lactis NCC 2287 significantly decreased relative expression levels of the Th-2 cytokine, IL-13, and associated chemokines CCL11 (eotaxin-1) and CCL17 (TARC) in the ileum.
No effect was observed in the jejunum.
Conclusion/Significance.
These results taken together designate Lactococcus lactis NCC 2287 as a candidate probiotic strain appropriate in the management of allergic symptoms.
American Psychological Association (APA)
Zuercher, Adrian W.& Weiss, Marietta& Holvoet, Sébastien& Moser, Mireille& Moussu, Hélène& van Overtvelt, Laurence…[et al.]. 2011. Lactococcus lactis NCC 2287 Alleviates Food Allergic Manifestations in Sensitized Mice by Reducing IL-13 Expression Specifically in the Ileum. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-475407
Modern Language Association (MLA)
Zuercher, Adrian W.…[et al.]. Lactococcus lactis NCC 2287 Alleviates Food Allergic Manifestations in Sensitized Mice by Reducing IL-13 Expression Specifically in the Ileum. Clinical and Developmental Immunology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-475407
American Medical Association (AMA)
Zuercher, Adrian W.& Weiss, Marietta& Holvoet, Sébastien& Moser, Mireille& Moussu, Hélène& van Overtvelt, Laurence…[et al.]. Lactococcus lactis NCC 2287 Alleviates Food Allergic Manifestations in Sensitized Mice by Reducing IL-13 Expression Specifically in the Ileum. Clinical and Developmental Immunology. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-475407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475407