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Positive and Negative Regulation of Cellular Immune Responses in Physiologic Conditions and Diseases
Joint Authors
Harari, Alexandre
Viganò, Selena
Pantaleo, Giuseppe
Perreau, Matthieu
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The immune system has evolved to allow robust responses against pathogens while avoiding autoimmunity.
This is notably enabled by stimulatory and inhibitory signals which contribute to the regulation of immune responses.
In the presence of a pathogen, a specific and effective immune response must be induced and this leads to antigen-specific T-cell proliferation, cytokines production, and induction of T-cell differentiation toward an effector phenotype.
After clearance or control of the pathogen, the effector immune response must be terminated in order to avoid tissue damage and chronic inflammation and this process involves coinhibitory molecules.
When the immune system fails to eliminate or control the pathogen, continuous stimulation of T cells prevents the full contraction and leads to the functional exhaustion of effector T cells.
Several evidences both in vitro and in vivo suggest that this anergic state can be reverted by blocking the interactions between coinhibitory molecules and their ligands.
The potential to revert exhausted or inactivated T-cell responses following selective blocking of their function made these markers interesting targets for therapeutic interventions in patients with persistent viral infections or cancer.
American Psychological Association (APA)
Viganò, Selena& Perreau, Matthieu& Pantaleo, Giuseppe& Harari, Alexandre. 2012. Positive and Negative Regulation of Cellular Immune Responses in Physiologic Conditions and Diseases. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-475412
Modern Language Association (MLA)
Viganò, Selena…[et al.]. Positive and Negative Regulation of Cellular Immune Responses in Physiologic Conditions and Diseases. Clinical and Developmental Immunology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-475412
American Medical Association (AMA)
Viganò, Selena& Perreau, Matthieu& Pantaleo, Giuseppe& Harari, Alexandre. Positive and Negative Regulation of Cellular Immune Responses in Physiologic Conditions and Diseases. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-475412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475412