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The Yin and Yang of Nrf2-Regulated Selenoproteins in Carcinogenesis
Joint Authors
Kipp, Anna Patricia
Brigelius-Flohé, Regina
Lippmann, Doris
Müller, Mike
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The NF-E2-related factor-2 (Nrf2) is a transcription factor which regulates the major cellular defense systems and thereby contributes to the prevention of many diseases including cancer.
Selenium deficiency is associated with a higher cancer risk making also this essential trace element a promising candidate for cancer prevention.
Two selenoproteins, thioredoxin reductase-1 (TrxR1) and glutathione peroxidase-2 (GPx2), are targets for Nrf2.
Selenium deficiency activates Nrf2 as does a TrxR1 knockout making a synergism between both systems plausible.
Although this might hold true for healthy cells, the interplay may turn into the opposite in cancer cells.
The induction of the detoxifying and antioxidant enzymes by Nrf2 will make cancer cells chemoresistant and will protect them against oxidative damage.
The essential role of TrxR1 in maintaining proliferation makes its upregulation in cancer cells detrimental.
The anti-inflammatory potential of GPx2 will help to inhibit cancer initiation and inflammation-triggered promotion, but its growth supporting potential will also support tumor growth.
This paper considers beneficial and adverse consequences of the activation of Nrf2 and the selenoproteins which appear to depend on the cancer stage.
American Psychological Association (APA)
Brigelius-Flohé, Regina& Müller, Mike& Lippmann, Doris& Kipp, Anna Patricia. 2012. The Yin and Yang of Nrf2-Regulated Selenoproteins in Carcinogenesis. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-475451
Modern Language Association (MLA)
Brigelius-Flohé, Regina…[et al.]. The Yin and Yang of Nrf2-Regulated Selenoproteins in Carcinogenesis. International Journal of Cell Biology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-475451
American Medical Association (AMA)
Brigelius-Flohé, Regina& Müller, Mike& Lippmann, Doris& Kipp, Anna Patricia. The Yin and Yang of Nrf2-Regulated Selenoproteins in Carcinogenesis. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-475451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475451