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Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People : A Systematic Review with Meta-Analyses
Joint Authors
de Groot, C. P. G. M.
Duffy, M. E.
Souverein, Olga W.
Pietruszka, B.
Dullemeijer, Carla
Doets, E. L.
van't Veer, Pieter
van Wijngaarden, J. P.
Szczecińska, A.
Dhonukshe-Rutten, R. A. M.
Brzozowska, Anna
Cavelaars, A. E. J. M.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-20
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Elevated homocysteine levels and low vitamin B12 and folate levels have been associated with deteriorated bone health.
This systematic literature review with dose-response meta-analyses summarizes the available scientific evidence on associations of vitamin B12, folate, and homocysteine status with fractures and bone mineral density (BMD).
Twenty-seven eligible cross-sectional (n=14) and prospective (n=13) observational studies and one RCT were identified.
Meta-analysis on four prospective studies including 7475 people showed a modest decrease in fracture risk of 4% per 50 pmol/L increase in vitamin B12 levels, which was borderline significant (RR = 0.96, 95% CI = 0.92 to 1.00).
Meta-analysis of eight studies including 11511 people showed an increased fracture risk of 4% per μmol/L increase in homocysteine concentration (RR = 1.04, 95% CI = 1.02 to 1.07).
We could not draw a conclusion regarding folate levels and fracture risk, as too few studies investigated this association.
Meta-analyses regarding vitamin B12, folate and homocysteine levels, and BMD were possible in female populations only and showed no associations.
Results from studies regarding BMD that could not be included in the meta-analyses were not univocal.
American Psychological Association (APA)
van Wijngaarden, J. P.& Doets, E. L.& Szczecińska, A.& Souverein, Olga W.& Duffy, M. E.& Dullemeijer, Carla…[et al.]. 2013. Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People : A Systematic Review with Meta-Analyses. Journal of Nutrition and Metabolism،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-475459
Modern Language Association (MLA)
van Wijngaarden, J. P.…[et al.]. Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People : A Systematic Review with Meta-Analyses. Journal of Nutrition and Metabolism No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-475459
American Medical Association (AMA)
van Wijngaarden, J. P.& Doets, E. L.& Szczecińska, A.& Souverein, Olga W.& Duffy, M. E.& Dullemeijer, Carla…[et al.]. Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People : A Systematic Review with Meta-Analyses. Journal of Nutrition and Metabolism. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-475459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475459