Oxidative Stress and Pulmonary Changes in Experimental Liver Cirrhosis
Joint Authors
Forgiarini, Luiz Felipe
Bona, Sílvia
Salatti Ferrari, Renata
da Rosa, Darlan Pase
Marroni, Norma Anair Possa
Simões Dias, Alexandre
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The use of carbon tetrachloride (CCl4) in rats is an experimental model of hepatic tissue damage; which leads to fibrosis, and at the long term, cirrhosis.
Cirrhosis is the consequence of progressive continued liver damage, it may be reversible when the damaging noxae have been withdrawn.
The aim of this study is to evaluate the changes caused by cirrhosis in lung and liver, through the experimental model of intraperitoneal CCI4 administration.
We used 18 male Wistar rats divided into three groups: control (CO) and two groups divided by the time of cirrhosis induction by CCI4: G1 (11 weeks), G2 (16 weeks).
We found significant increase of transaminase levels and lipid peroxidation (TBARS) in liver and lung tissue and also increased antioxidant enzymes SOD and CAT, as well as the expression of TNF-α and IL-1β in the lung of cirrhotic animals.
We observed changes in gas exchange in both cirrhotic groups.
We can conclude that our model reproduces a model of liver cirrhosis, which causes alterations in the pulmonary system that leads to changes in gas exchange and size of pulmonary vessels.
American Psychological Association (APA)
Salatti Ferrari, Renata& da Rosa, Darlan Pase& Forgiarini, Luiz Felipe& Bona, Sílvia& Simões Dias, Alexandre& Marroni, Norma Anair Possa. 2012. Oxidative Stress and Pulmonary Changes in Experimental Liver Cirrhosis. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-475461
Modern Language Association (MLA)
Salatti Ferrari, Renata…[et al.]. Oxidative Stress and Pulmonary Changes in Experimental Liver Cirrhosis. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-475461
American Medical Association (AMA)
Salatti Ferrari, Renata& da Rosa, Darlan Pase& Forgiarini, Luiz Felipe& Bona, Sílvia& Simões Dias, Alexandre& Marroni, Norma Anair Possa. Oxidative Stress and Pulmonary Changes in Experimental Liver Cirrhosis. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-475461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475461