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Effect of Autologous Platelet Rich Fibrin on the Healing of Experimental Articular Cartilage Defects of the Knee in an Animal Model
Joint Authors
Mirzazadeh Dizaji, Vahid
Fakhrjou, Ashraf
Khanzadeh Alishahi, Majid
Kazemi, Davoud
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The effect of autologous platelet rich fibrin (PRF), a second generation platelet product, on the healing of experimental articular cartilage lesions was evaluated in an animal model.
Full thickness cartilage lesions with a diameter of 6 mm and depth of 5 mm were created in the weight bearing area of femoral condyles of both hind limbs in 12 adult mixed breed dogs.
Defects in the left hind limb of each dog were repaired by PRF implantation whereas those in the right hind limb were left empty.
The animals were euthanized at 4, 16, and 24 weeks following surgery and the resultant repair tissue was investigated macroscopically and microscopically.
The results of macroscopic and histological evaluations indicated that there were significant differences between the PRF treated and untreated defects.
In conclusion, the present study indicated that the use of platelet rich fibrin as a source of autologous growth factors leads to improvement in articular cartilage repair.
American Psychological Association (APA)
Kazemi, Davoud& Fakhrjou, Ashraf& Mirzazadeh Dizaji, Vahid& Khanzadeh Alishahi, Majid. 2014. Effect of Autologous Platelet Rich Fibrin on the Healing of Experimental Articular Cartilage Defects of the Knee in an Animal Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-475493
Modern Language Association (MLA)
Kazemi, Davoud…[et al.]. Effect of Autologous Platelet Rich Fibrin on the Healing of Experimental Articular Cartilage Defects of the Knee in an Animal Model. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-475493
American Medical Association (AMA)
Kazemi, Davoud& Fakhrjou, Ashraf& Mirzazadeh Dizaji, Vahid& Khanzadeh Alishahi, Majid. Effect of Autologous Platelet Rich Fibrin on the Healing of Experimental Articular Cartilage Defects of the Knee in an Animal Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-475493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475493