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Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules
Joint Authors
Lenart, Izabela
Antoniou, Antony N.
Guiliano, David B.
Source
International Journal of Rheumatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The association between HLA-B27 and the group of autoimmune inflammatory arthritic diseases, the spondyloarthropathies (SpAs) which include ankylosing spondylitis (AS) and Reactive Arthritis (ReA), has been well established and remains the strongest association between any HLA molecule and autoimmune disease.
The mechanism behind this striking association remains elusive; however animal model and biochemical data suggest that HLA-B27 misfolding may be key to understanding its association with the SpAs.
Recent investigations have focused on the unusual biochemical structures of HLA-B27 and their potential role in SpA pathogenesis.
Here we discuss how these unusual biochemical structures may participate in cellular events leading to chronic inflammation and thus disease progression.
American Psychological Association (APA)
Antoniou, Antony N.& Lenart, Izabela& Guiliano, David B.. 2011. Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules. International Journal of Rheumatology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-475520
Modern Language Association (MLA)
Antoniou, Antony N.…[et al.]. Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules. International Journal of Rheumatology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-475520
American Medical Association (AMA)
Antoniou, Antony N.& Lenart, Izabela& Guiliano, David B.. Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules. International Journal of Rheumatology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-475520
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475520