The Involvement of Glutamate Metabolism in the Resistance to Thermal, Nutritional, and Oxidative Stress in Trypanosoma cruzi
Joint Authors
Rocha, Sandra C.
Suárez Mantilla, Brian
Pral, Elizabeth M. F.
Silber, Ariel Mariano
Magdaleno, Anahí
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The inhibition of some glutamate metabolic pathways could lead to diminished parasite survival.
In this study, the effects of L-methionine sulfoximine (MS), DL-methionine sulfone (MSO), and DL-methionine sulfoxide (MSE), three glutamate analogs, on several biological processes were evaluated.
We found that these analogs inhibited the growth of epimastigotes cells and showed a synergistic effect with stress conditions such as temperature, nutritional starvation, and oxidative stress.
The specific activity for the reductive amination of α-ketoglutaric acid, catalyzed by the NADP+-linked glutamate dehydrogenase, showed an increase in the NADP+ levels, when MS, MSE, and MSO were added.
It suggests an eventual conversion of the compounds tested by the T.
cruzi cells.
The fact that trypomastigote bursting was not significantly inhibited when infected cells were treated with these compounds, remarks the existence of relevant metabolic differences among the different life-cycle stages.
It must be considered when proposing a new therapeutic drug.
American Psychological Association (APA)
Magdaleno, Anahí& Suárez Mantilla, Brian& Rocha, Sandra C.& Pral, Elizabeth M. F.& Silber, Ariel Mariano. 2011. The Involvement of Glutamate Metabolism in the Resistance to Thermal, Nutritional, and Oxidative Stress in Trypanosoma cruzi. Enzyme Research،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-475523
Modern Language Association (MLA)
Magdaleno, Anahí…[et al.]. The Involvement of Glutamate Metabolism in the Resistance to Thermal, Nutritional, and Oxidative Stress in Trypanosoma cruzi. Enzyme Research No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-475523
American Medical Association (AMA)
Magdaleno, Anahí& Suárez Mantilla, Brian& Rocha, Sandra C.& Pral, Elizabeth M. F.& Silber, Ariel Mariano. The Involvement of Glutamate Metabolism in the Resistance to Thermal, Nutritional, and Oxidative Stress in Trypanosoma cruzi. Enzyme Research. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-475523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475523