Liver Cancer Stem Cells
Joint Authors
Source
International Journal of Hepatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Hepatocellular carcinoma is the most common primary malignancy of the liver in adults.
It is also the fifth most common solid cancer worldwide and the third leading cause of cancer-related death.
Recent research supports that liver cancer is a disease of adult stem cells.
From the models of experimental hepatocarcinogenesis, there may be at least three distinct cell lineages with progenitor properties susceptible to neoplastic transformation.
Identification of specific cell surface markers for each of the liver cell types, production of corresponding monoclonal antibodies and cell sorting techniques have together revolutionized the characteristics of normal stem cells.
In hepatocarcinogenesis, multiple signaling transduction pathways, important for stem cell proliferation and differentiations, are deregulated.
Strategies are being developed to identify and characterize the liver cancer stem cells.
Targeting liver cancer stem cells may bring hope to curing hepatocellular carcinoma.
American Psychological Association (APA)
Mikhail, Sameh& He, Aiwu Ruth. 2011. Liver Cancer Stem Cells. International Journal of Hepatology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-475526
Modern Language Association (MLA)
Mikhail, Sameh& He, Aiwu Ruth. Liver Cancer Stem Cells. International Journal of Hepatology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-475526
American Medical Association (AMA)
Mikhail, Sameh& He, Aiwu Ruth. Liver Cancer Stem Cells. International Journal of Hepatology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-475526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475526