The Endotoxin-Induced Neuroinflammation Model of Parkinson's Disease
Joint Authors
Genc, Sermin
Tufekci, Kemal Ugur
Genc, Kursad
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-18
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra.
Although the exact cause of the dopaminergic neurodegeneration remains elusive, recent postmortem and experimental studies have revealed an essential role for neuroinflammation that is initiated and driven by activated microglial and infiltrated peripheral immune cells and their neurotoxic products (such as proinflammatory cytokines, reactive oxygen species, and nitric oxide) in the pathogenesis of PD.
A bacterial endotoxin-based experimental model of PD has been established, representing a purely inflammation-driven animal model for the induction of nigrostriatal dopaminergic neurodegeneration.
This model, by itself or together with genetic and toxin-based animal models, provides an important tool to delineate the precise mechanisms of neuroinflammation-mediated dopaminergic neuron loss.
Here, we review the characteristics of this model and the contribution of neuroinflammatory processes, induced by the in vivo administration of bacterial endotoxin, to neurodegeneration.
Furthermore, we summarize the recent experimental therapeutic strategies targeting endotoxin-induced neuroinflammation to elicit neuroprotection in the nigrostriatal dopaminergic system.
The potential of the endotoxin-based PD model in the development of an early-stage specific diagnostic biomarker is also emphasized.
American Psychological Association (APA)
Tufekci, Kemal Ugur& Genc, Sermin& Genc, Kursad. 2011. The Endotoxin-Induced Neuroinflammation Model of Parkinson's Disease. Advances in Urology،Vol. 2011, no. 2011, pp.1-25.
https://search.emarefa.net/detail/BIM-475578
Modern Language Association (MLA)
Tufekci, Kemal Ugur…[et al.]. The Endotoxin-Induced Neuroinflammation Model of Parkinson's Disease. Advances in Urology No. 2011 (2011), pp.1-25.
https://search.emarefa.net/detail/BIM-475578
American Medical Association (AMA)
Tufekci, Kemal Ugur& Genc, Sermin& Genc, Kursad. The Endotoxin-Induced Neuroinflammation Model of Parkinson's Disease. Advances in Urology. 2011. Vol. 2011, no. 2011, pp.1-25.
https://search.emarefa.net/detail/BIM-475578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475578