Acute Liver Failure Caused by Amanita phalloides Poisoning
Joint Authors
Caraceni, Paolo
Mastroroberto, Marianna
Napoli, Lucia
Tufoni, Manuel
Santi, Luca
Maggioli, Caterina
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Mushroom poisoning is a relatively rare cause of acute liver failure (ALF).
The present paper analyzes the pathogenesis, clinical features, prognostic indicators, and therapeutic strategies of ALF secondary to ingestion of Amanita phalloides, which represents the most common and deadly cause of mushroom poisoning.
Liver damage from Amanita phalloides is related to the amanitins, powerful toxins that inhibit RNA polymerase II resulting in a deficient protein synthesis and cell necrosis.
After an asymptomatic lag phase, the clinical picture is characterized by gastrointestinal symptoms, followed by the liver and kidney involvement.
Amatoxin poisoning may progress into ALF and eventually death if liver transplantation is not performed.
The mortality rate after Amanita phalloides poisoning ranges from 10 to 20%.
The management of amatoxin poisoning consists of preliminary medical care, supportive measures, detoxification therapies, and orthotopic liver transplantation.
The clinical efficacy of any modality of treatment is difficult to demonstrate since randomized, controlled clinical trials have not been reported.
The use of extracorporeal liver assist devices as well as auxiliary liver transplantation may represent additional therapeutic options.
American Psychological Association (APA)
Santi, Luca& Maggioli, Caterina& Mastroroberto, Marianna& Tufoni, Manuel& Napoli, Lucia& Caraceni, Paolo. 2012. Acute Liver Failure Caused by Amanita phalloides Poisoning. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-475579
Modern Language Association (MLA)
Santi, Luca…[et al.]. Acute Liver Failure Caused by Amanita phalloides Poisoning. International Journal of Hepatology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-475579
American Medical Association (AMA)
Santi, Luca& Maggioli, Caterina& Mastroroberto, Marianna& Tufoni, Manuel& Napoli, Lucia& Caraceni, Paolo. Acute Liver Failure Caused by Amanita phalloides Poisoning. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-475579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475579