Statins Attenuate the Increase in P-Selectin Produced by Prolonged Exercise
Joint Authors
Zaleski, Amanda L.
Ballard, Kevin D.
Parker, Beth
Baggish, Aaron
Capizzi, Jeffrey
Thompson, Paul D.
D'Hemecourt, Pierre
Troyanos, Christopher
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Strenuous endurance exercise increases inflammatory markers and acutely increases cardiovascular risk; however, statins may mitigate this response.
We measured serum levels of p-selectin in 37 runners treated with statins and in 43 nonstatin treated controls running the 2011 Boston Marathon.
Venous blood samples were obtained the day before (PRE) as well as within 1 hour after (FINISH) and 24 hours after (POST) the race.
The increase in p-selectin immediately after exercise was lower in statin users (PRE to FINISH: 20.5 ± 19.4 ng/mL) than controls (PRE to FINISH: 30.9 ± 27.1 ng/mL; P<0.001).
The increase in p-selectin 24 hours after exercise was also lower in statin users (PRE to POST: 21.5 ± 26.6 ng/mL) than controls (PRE to POST: 29.3 ± 31.9 ng/mL; P<0.001).
Furthermore, LDL-C was positively correlated with p-selectin at FINISH and POST (P<0.01 and P<0.05, resp.), irrespective of drug treatment, suggesting that lower levels of LDL-C are associated with a reduced inflammatory response to exercise.
We conclude that statins blunt the exercise-induced increase in p-selectin following a marathon and that the inflammatory response to a marathon varies directly with LDL-C levels.
American Psychological Association (APA)
Zaleski, Amanda L.& Capizzi, Jeffrey& Ballard, Kevin D.& Troyanos, Christopher& Baggish, Aaron& D'Hemecourt, Pierre…[et al.]. 2013. Statins Attenuate the Increase in P-Selectin Produced by Prolonged Exercise. Journal of Sports Medicine،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-475592
Modern Language Association (MLA)
Zaleski, Amanda L.…[et al.]. Statins Attenuate the Increase in P-Selectin Produced by Prolonged Exercise. Journal of Sports Medicine No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-475592
American Medical Association (AMA)
Zaleski, Amanda L.& Capizzi, Jeffrey& Ballard, Kevin D.& Troyanos, Christopher& Baggish, Aaron& D'Hemecourt, Pierre…[et al.]. Statins Attenuate the Increase in P-Selectin Produced by Prolonged Exercise. Journal of Sports Medicine. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-475592
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475592