Cellular Factors Implicated in Filovirus Entry
Joint Authors
Hope, Thomas J.
Bhattacharyya, Suchita
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Although filoviral infections are still occurring in different parts of the world, there are no effective preventive or treatment strategies currently available against them.
Not only do filoviruses cause a deadly infection, but they also have the potential of being used as biological weapons.
This makes it imperative to comprehensively study these viruses in order to devise effective strategies to prevent the occurrence of these infections.
Entry is the foremost step in the filoviral replication cycle and different studies have reported the involvement of a myriad of cellular factors including plasma membrane components, cytoskeletal proteins, endosomal components, and cytosolic factors in this process.
Signaling molecules such as the TAM family of receptor tyrosine kinases comprising of Tyro3, Axl, and Mer have also been implicated as putative entry factors.
Additionally, filoviruses are suggested to bind to a common receptor and recent studies have proposed T-cell immunoglobulin and mucin domain 1 (TIM-1) and Niemann-Pick C1 (NPC1) as potential receptor candidates.
This paper summarizes the existing literature on filoviral entry with a special focus on cellular factors involved in this process and also highlights some fundamental questions.
Future research aimed at answering these questions could be very useful in designing novel antiviral therapeutics.
American Psychological Association (APA)
Bhattacharyya, Suchita& Hope, Thomas J.. 2013. Cellular Factors Implicated in Filovirus Entry. Advances in Virology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-475596
Modern Language Association (MLA)
Bhattacharyya, Suchita& Hope, Thomas J.. Cellular Factors Implicated in Filovirus Entry. Advances in Virology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-475596
American Medical Association (AMA)
Bhattacharyya, Suchita& Hope, Thomas J.. Cellular Factors Implicated in Filovirus Entry. Advances in Virology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-475596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475596