Evaluation of a Subunit H5 Vaccine and an Inactivated H5N2 Avian Influenza Marker Vaccine in Ducks Challenged with Vietnamese H5N1 Highly Pathogenic Avian Influenza Virus
Joint Authors
Leung, Connie Y. H.
Chow, Chun-Kin
Sia, Sin-Fun
Ma, Siu-Kit
Ellis, Trevor M.
Fenwick, Stanley G.
Peiris, J. S. Malik
Chua, Tze-Hoong
Chua, Sin Bin
Kwang, Jimmy
Chew, Siang Thai
Ng, Iris H. Y.
Fang, H. E.
James, Cassandra M.
Source
Influenza Research and Treatment
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The protective efficacy of a subunit avian influenza virus H5 vaccine based on recombinant baculovirus expressed H5 haemagglutinin antigen and an inactivated H5N2 avian influenza vaccine combined with a marker antigen (tetanus toxoid) was compared with commercially available inactivated H5N2 avian influenza vaccine in young ducks.
Antibody responses, morbidity, mortality, and virus shedding were evaluated after challenge with a Vietnamese clade 1 H5N1 HPAI virus [A/VN/1203/04 (H5N1)] that was known to cause a high mortality rate in ducks.
All three vaccines, administered with water-in-oil adjuvant, provided significant protection and dramatically reduced the duration and titer of virus shedding in the vaccinated challenged ducks compared with unvaccinated controls.
The H5 subunit vaccine was shown to provide equivalent protection to the other two vaccines despite the H5 antibody responses in subunit vaccinated ducks being significantly lower prior to challenge.
Ducks vaccinated with the H5N2 marker vaccine consistently produced antitetanus toxoid antibody.
The two novel vaccines have attributes that would enhance H5N1 avian influenza surveillance and control by vaccination in small scale and village poultry systems.
American Psychological Association (APA)
Chua, Tze-Hoong& Leung, Connie Y. H.& Fang, H. E.& Chow, Chun-Kin& Ma, Siu-Kit& Sia, Sin-Fun…[et al.]. 2010. Evaluation of a Subunit H5 Vaccine and an Inactivated H5N2 Avian Influenza Marker Vaccine in Ducks Challenged with Vietnamese H5N1 Highly Pathogenic Avian Influenza Virus. Influenza Research and Treatment،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-475651
Modern Language Association (MLA)
Chua, Tze-Hoong…[et al.]. Evaluation of a Subunit H5 Vaccine and an Inactivated H5N2 Avian Influenza Marker Vaccine in Ducks Challenged with Vietnamese H5N1 Highly Pathogenic Avian Influenza Virus. Influenza Research and Treatment No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-475651
American Medical Association (AMA)
Chua, Tze-Hoong& Leung, Connie Y. H.& Fang, H. E.& Chow, Chun-Kin& Ma, Siu-Kit& Sia, Sin-Fun…[et al.]. Evaluation of a Subunit H5 Vaccine and an Inactivated H5N2 Avian Influenza Marker Vaccine in Ducks Challenged with Vietnamese H5N1 Highly Pathogenic Avian Influenza Virus. Influenza Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-475651
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475651