The Effects of α-Lipoic Acid against Testicular Ischemia-Reperfusion Injury in Rats
Joint Authors
Cavdar, Z.
Erbil, G.
Ergur, Bekir Ugur
Bagrıyanık, A.
Ozbal, Seda
Tekmen, I.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Testicular torsion is one of the urologic emergencies occurring frequently in neonatal and adolescent period.
Testis is sensitive to ischemia-reperfusion injury, and, therefore, ischemia and consecutive reperfusion cause an enhanced formation of reactive oxygen species that result in testicular cell damage and apoptosis.
α-lipoic acid is a free radical scavenger and a biological antioxidant.
It is widely used in the prevention of oxidative stress and cellular damage.
We aimed to investigate the protective effect of α-lipoic acid on testicular damage in rats subjected to testicular ischemia-reperfusion injury.
35 rats were randomly divided into 5 groups: control, sham operated, ischemia, ischemia-reperfusion, and ischemia-reperfusion +lipoic acid groups, 2 h torsion and 2 h detorsion of the testis were performed.
Testicular cell damage was examined by H-E staining.
TUNEL and active caspase-3 immunostaining were used to detect germ cell apoptosis.
GPx , SOD activity, and MDA levels were evaluated.
Histological evaluation showed that α-lipoic acid pretreatment reduced testicular cell damage and decreased TUNEL and caspase-3-positive cells.
Additionally, α-lipoic acid administration decreased the GPx and SOD activity and increased the MDA levels.
The present results suggest that LA is a potentially beneficial agent in protecting testicular I/R in rats.
American Psychological Association (APA)
Ozbal, Seda& Ergur, Bekir Ugur& Erbil, G.& Tekmen, I.& Bagrıyanık, A.& Cavdar, Z.. 2012. The Effects of α-Lipoic Acid against Testicular Ischemia-Reperfusion Injury in Rats. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-475654
Modern Language Association (MLA)
Ozbal, Seda…[et al.]. The Effects of α-Lipoic Acid against Testicular Ischemia-Reperfusion Injury in Rats. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-475654
American Medical Association (AMA)
Ozbal, Seda& Ergur, Bekir Ugur& Erbil, G.& Tekmen, I.& Bagrıyanık, A.& Cavdar, Z.. The Effects of α-Lipoic Acid against Testicular Ischemia-Reperfusion Injury in Rats. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-475654
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475654