Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease
Joint Authors
El Khoury, Joseph
Wilkinson, Kim
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is increasing in prevalence with the aging population.
Deposition of amyloid-β (Aβ) in the brain of AD patients is a hallmark of the disease and is associated with increased microglial numbers and activation state.
The interaction of microglia with Aβ appears to play a dichotomous role in AD pathogenesis.
On one hand, microglia can phagocytose and clear Aβ, but binding of microglia to Aβ also increases their ability to produce inflammatory cytokines, chemokines, and neurotoxic reactive oxygen species (ROS).
Scavenger receptors, a group of evolutionally conserved proteins expressed on the surface of microglia act as receptors for Aβ.
Of particular interest are SCARA-1 (scavenger receptor A-1), CD36, and RAGE (receptor for advanced glycation end products).
SCARA-1 appears to be involved in the clearance of Aβ, while CD36 and RAGE are involved in activation of microglia by Aβ.
In this review, we discuss the roles of various scavenger receptors in the interaction of microglia with Aβ and propose that these receptors play complementary, nonredundant functions in the development of AD pathology.
We also discuss potential therapeutic applications for these receptors in AD.
American Psychological Association (APA)
Wilkinson, Kim& El Khoury, Joseph. 2012. Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-475675
Modern Language Association (MLA)
Wilkinson, Kim& El Khoury, Joseph. Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-475675
American Medical Association (AMA)
Wilkinson, Kim& El Khoury, Joseph. Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-475675
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475675