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Prognostic Significance of Sentinel Lymph Node Mapping in Merkel Cell Carcinoma : Systematic Review and Meta-Analysis of Prognostic Studies
Joint Authors
Fallahi, Babak
Treglia, Giorgio
Sadeghi, Ramin
Giovanella, Luca
Adinehpoor, Zohreh
Maleki, Masoud
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
To assess through a systematic review and meta-analysis of the literature the prognostic implication of sentinel lymph node mapping in Merkel cell carcinoma (MCC).
Materials and Methods.
PubMed and SCOPUS databases were searched by using “Merkel AND sentinel” as keywords.
All studies with prognostic information regarding SLN mapping in cN0 MCC patients were included.
Hazard ratio (HR) for overall survival (OS) and disease free survival (DFS) was used as effect size.
Results.
SLN biopsy predicted better DFS and OS as compared to the nodal observation in cN0 MCC patients (pooled HR for DFS: 1.61 (95% CI: 1.05–2.46), P=0.028; pooled HR for OS: 1.08 (95% CI: 0.55–2.10), P=0.8).
Pathologically negative SLN (SLN−) patients had better OS (pooled HR: 4.42 (95% CI: 1.82–10.7), P=0.0009) and DFS (pooled HR: 2.58 (95% CI: 1.78–3.73)) as compared to SLN+ patients.
Conclusion.
SLN mapping can provide strong prognostic information regarding OS and DFS in cN0 MCC patients.
More importantly, SLN mapping can improve DFS and possibly OS in cN0 MCC patients as compared to nodal observation.
As MCC is a rare tumor, large multicenter prospective studies are still needed to validate the survival benefit of SLN mapping.
American Psychological Association (APA)
Sadeghi, Ramin& Adinehpoor, Zohreh& Maleki, Masoud& Fallahi, Babak& Giovanella, Luca& Treglia, Giorgio. 2014. Prognostic Significance of Sentinel Lymph Node Mapping in Merkel Cell Carcinoma : Systematic Review and Meta-Analysis of Prognostic Studies. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-475681
Modern Language Association (MLA)
Sadeghi, Ramin…[et al.]. Prognostic Significance of Sentinel Lymph Node Mapping in Merkel Cell Carcinoma : Systematic Review and Meta-Analysis of Prognostic Studies. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-475681
American Medical Association (AMA)
Sadeghi, Ramin& Adinehpoor, Zohreh& Maleki, Masoud& Fallahi, Babak& Giovanella, Luca& Treglia, Giorgio. Prognostic Significance of Sentinel Lymph Node Mapping in Merkel Cell Carcinoma : Systematic Review and Meta-Analysis of Prognostic Studies. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-475681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475681