Phasic and Tonic Smooth Muscle Function of the Partially Obstructed Guinea Pig Intestine
Joint Authors
Zhao, Jingbo
Yang, Jian
Gregersen, Hans
Liao, Donghua
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study was to generate phasic and tonic stress-strain curves for evaluation of smooth muscle function in the obstructed guinea pig jejunum.
Partial and sham obstruction of the jejunum in guinea pigs was created surgically, with guinea pigs not being operated on served as normal controls.
The animals survived 2, 4, 7, and 14 days, respectively.
The jejunal segment was distended to 10 cm H2O.
The pressure and outer diameter changes were recorded.
Passive conditions were obtained by using papaverine.
Total phasic, tonic, and passive circumferential stress and strain were computed from the diameter and pressure data with reference to the zero-stress-state geometry.
The active phasic and tonic stresses were defined as the total phasic and tonic stress minus the passive stress.
The thickness of intestinal muscle layers increased in a time-dependent manner after obstruction.
The amplitude of passive, total phasic, total tonic, active phasic, and active tonic circumferential stresses increased as function of strain 7 days after obstruction.
However, when normalized to muscle layer thickness, the amplitude of active stresses did not differ among the groups.
In conclusion, the long-term-obstructed intestine exhibits increased total smooth muscle contraction force.
However, the contraction force per smooth muscle unit did not increase.
American Psychological Association (APA)
Zhao, Jingbo& Liao, Donghua& Yang, Jian& Gregersen, Hans. 2011. Phasic and Tonic Smooth Muscle Function of the Partially Obstructed Guinea Pig Intestine. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-475700
Modern Language Association (MLA)
Zhao, Jingbo…[et al.]. Phasic and Tonic Smooth Muscle Function of the Partially Obstructed Guinea Pig Intestine. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-475700
American Medical Association (AMA)
Zhao, Jingbo& Liao, Donghua& Yang, Jian& Gregersen, Hans. Phasic and Tonic Smooth Muscle Function of the Partially Obstructed Guinea Pig Intestine. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-475700
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475700