Genetics and Epigenetics of Parkinson's Disease
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
In 1997 a mutation in the a-synuclein (SNCA) gene was associated with familial autosomal dominant Parkinson’s disease (PD).
Since then, several loci (PARK1-15) and genes have been linked to familial forms of the disease.
There is now sufficient evidence that six of the so far identified genes at PARK loci (a-synuclein, leucine-rich repeat kinase 2, parkin, PTEN-induced putative kinase 1, DJ-1, and ATP13A2) cause inherited forms of typical PD or parkinsonian syndromes.
Other genes at non-PARK loci (MAPT, SCA1, SCA2, spatacsin, POLG1) cause syndromes with parkinsonism as one of the symptoms.
The majority of PD cases are however sporadic “idiopathic” forms, and the recent application of genome-wide screening revealed almost 20 genes that might contribute to disease risk.
In addition, increasing evidence suggests that epigenetic mechanisms, such as DNA methylation, histone modifications, and small RNA-mediated mechanisms, could regulate the expression of PD-related genes.
American Psychological Association (APA)
Coppedè, Fabio. 2012. Genetics and Epigenetics of Parkinson's Disease. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-475713
Modern Language Association (MLA)
Coppedè, Fabio. Genetics and Epigenetics of Parkinson's Disease. The Scientific World Journal No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-475713
American Medical Association (AMA)
Coppedè, Fabio. Genetics and Epigenetics of Parkinson's Disease. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-475713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475713