Neuroimaging Measures as Endophenotypes in Alzheimer's Disease
Joint Authors
Ringman, John M.
Braskie, Meredith N.
Thompson, Paul M.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Late onset Alzheimer's disease (AD) is moderately to highly heritable.
Apolipoprotein E allele ε4 (APOE4) has been replicated consistently as an AD risk factor over many studies, and recently confirmed variants in other genes such as CLU, CR1, and PICALM each increase the lifetime risk of AD.
However, much of the heritability of AD remains unexplained.
AD is a complex disease that is diagnosed largely through neuropsychological testing, though neuroimaging measures may be more sensitive for detecting the incipient disease stages.
Difficulties in early diagnosis and variable environmental contributions to the disease can obscure genetic relationships in traditional case-control genetic studies.
Neuroimaging measures may be used as endophenotypes for AD, offering a reliable, objective tool to search for possible genetic risk factors.
Imaging measures might also clarify the specific mechanisms by which proposed risk factors influence the brain.
American Psychological Association (APA)
Braskie, Meredith N.& Ringman, John M.& Thompson, Paul M.. 2011. Neuroimaging Measures as Endophenotypes in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-475730
Modern Language Association (MLA)
Braskie, Meredith N.…[et al.]. Neuroimaging Measures as Endophenotypes in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-475730
American Medical Association (AMA)
Braskie, Meredith N.& Ringman, John M.& Thompson, Paul M.. Neuroimaging Measures as Endophenotypes in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-475730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475730