CD154 : An Immunoinflammatory Mediator in Systemic Lupus Erythematosus and Rheumatoid Arthritis
Joint Authors
Mourad, Walid
Hassan, Ghada S.
Alaaeddine, Nada
Yacoub, Daniel
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Systemic lupus erythematosus and rheumatoid arthritis are two major chronic inflammatory autoimmune diseases with significant prevalence rates among the population.
Although the etiology of these diseases remains unresolved, several evidences support the key role of CD154/CD40 interactions in initiating and/or propagating these diseases.
The discovery of new receptors (αIIbβ3, α5β1, and αMβ2) for CD154 has expanded our understanding about the precise role of this critical immune mediator in the physiopathology of chronic inflammatory autoimmune diseases in general, and in systemic lupus erythematosus and rheumatoid arthritis in particular.
This paper presents an overview of the interaction of CD154 with its various receptors and outlines its role in the pathogenesis of systemic lupus erythematosus and rheumatoid arthritis.
Moreover, the potential usefulness of various CD154-interfering agents in the treatment and prevention of these diseases is also discussed.
American Psychological Association (APA)
Alaaeddine, Nada& Hassan, Ghada S.& Yacoub, Daniel& Mourad, Walid. 2011. CD154 : An Immunoinflammatory Mediator in Systemic Lupus Erythematosus and Rheumatoid Arthritis. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-475732
Modern Language Association (MLA)
Alaaeddine, Nada…[et al.]. CD154 : An Immunoinflammatory Mediator in Systemic Lupus Erythematosus and Rheumatoid Arthritis. Clinical and Developmental Immunology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-475732
American Medical Association (AMA)
Alaaeddine, Nada& Hassan, Ghada S.& Yacoub, Daniel& Mourad, Walid. CD154 : An Immunoinflammatory Mediator in Systemic Lupus Erythematosus and Rheumatoid Arthritis. Clinical and Developmental Immunology. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-475732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475732