A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study
Joint Authors
Almasy, L.
Blangero, J.
Cole, S. A.
Stern, M. P.
Tracy, Russell P.
MacCluer, J. W.
Rainwater, D. L.
Diego, V. P.
Comuzzie, A. G.
Mahaney, M. C.
Source
International Journal of Vascular Medicine
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
D-dimer is associated with increasing severity of atherosclerosis and with increased risk of a cardiovascular disease (CVD).
Methods and Results.
To better understand this risk factor, we performed a genome scan on 803 (301 males and 502 females) Mexican Americans in the San Antonio Family Heart Study (SAFHS).
The SAFHS is ideal for the discovery of quantitative trait loci (QTLs) influencing CVD because CVD risk factors are prevalent in Mexican Americans of San Antonio and because the study design involves large families, which is optimal for QTL discovery.
D-dimer levels were normalized in our study.
We found that D-dimer levels were heritable, at about 23% heritability (P≈.00001).
In a linkage analysis employing 432 microsatellite markers, we found strong evidence of a QTL on chromosome 5p with a lod score of 3.32 at 21 centiMorgans (cM).
We also found suggestive evidence of a QTL on chromosome 2q with a lod score of 2.33 at 207 cM.
Conclusions.
To our knowledge, the putative QTL on chromosome 5p is novel.
The possible QTL on chromosome 2q is discussed in relation to a recent report of linkage of a related hemostatic factor to the same location.
These results warrant further investigation.
American Psychological Association (APA)
Diego, V. P.& Almasy, L.& Rainwater, D. L.& Mahaney, M. C.& Comuzzie, A. G.& Cole, S. A.…[et al.]. 2010. A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study. International Journal of Vascular Medicine،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-475740
Modern Language Association (MLA)
Diego, V. P.…[et al.]. A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study. International Journal of Vascular Medicine No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-475740
American Medical Association (AMA)
Diego, V. P.& Almasy, L.& Rainwater, D. L.& Mahaney, M. C.& Comuzzie, A. G.& Cole, S. A.…[et al.]. A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study. International Journal of Vascular Medicine. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-475740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475740