Design and Characterization of a Silk-Fibroin-Based Drug Delivery Platform Using Naproxen as a Model Drug
Joint Authors
Dyakonov, Tatyana
Fatmi, Aqeel
Bush, Derek
Yang, Chue Hue
Gosangari, Saujanya
Majuru, Shingai
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The objective of this proof-of-concept study was to develop a platform for controlled drug delivery based on silk fibroin (SF) and to explore the feasibility of using SF in oral drug delivery.
The SF-containing matrixes were prepared via spray-drying and film casting, and the release profile of the model drug naproxen sodium was evaluated.
Attenuated total reflectance Fourier transform infrared spectroscopy (FTIR) has been used to observe conformational changes in SF- and drug-containing compositions.
SF-based films, spray-dried microparticles, and matrixes loaded with naproxen were prepared.
Both FTIR spectra and in vitro dissolution data demonstrated that SF β-sheet conformation regulates the release profile of naproxen.
The controlled release characteristics of the SF-containing compositions were evaluated as a function of SF concentration, temperature, and exposure to dehydrating solvents.
The results suggest that SF may be an attractive polymer for use in controlled drug delivery systems.
American Psychological Association (APA)
Dyakonov, Tatyana& Yang, Chue Hue& Bush, Derek& Gosangari, Saujanya& Majuru, Shingai& Fatmi, Aqeel. 2012. Design and Characterization of a Silk-Fibroin-Based Drug Delivery Platform Using Naproxen as a Model Drug. Journal of Drug Delivery،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-475774
Modern Language Association (MLA)
Dyakonov, Tatyana…[et al.]. Design and Characterization of a Silk-Fibroin-Based Drug Delivery Platform Using Naproxen as a Model Drug. Journal of Drug Delivery No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-475774
American Medical Association (AMA)
Dyakonov, Tatyana& Yang, Chue Hue& Bush, Derek& Gosangari, Saujanya& Majuru, Shingai& Fatmi, Aqeel. Design and Characterization of a Silk-Fibroin-Based Drug Delivery Platform Using Naproxen as a Model Drug. Journal of Drug Delivery. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-475774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475774