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Rapid Evolution to Blast Crisis Associated with a Q252H ABL1 Kinase Domain Mutation in e19a2 BCR-ABL1 Chronic Myeloid Leukaemia
Joint Authors
Kelly, Johanna
Ryan, Mary F.
Langabeer, Stephen E.
McCarron, Sarah L.
Maher, Karena
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-16
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A minority of chronic myeloid leukaemia (CML) patients express variant transcripts of which the e19a2 BCR-ABL1 fusion is the most common.
Instances of tyrosine kinase inhibitor (TKI) resistance in e19a2 BCR-ABL1 CML patients have rarely been reported.
A case of e19a2 BCR-ABL1 CML is described in whom imatinib resistance, associated with a Q252H ABL1 kinase domain mutation, became apparent soon after initiation of TKI therapy.
The patient rapidly transformed to myeloid blast crisis (BC) with considerable bone marrow fibrosis and no significant molecular response to a second generation TKI.
The clinical course was complicated by comorbidities with the patient rapidly succumbing to advanced disease.
This scenario of Q252H-associated TKI resistance with rapid BC transformation has not been previously documented in e19a2 BCR-ABL1 CML.
This case highlights the considerable challenges remaining in the management of TKI-resistant BC CML, particularly in the elderly patient.
American Psychological Association (APA)
McCarron, Sarah L.& Maher, Karena& Kelly, Johanna& Ryan, Mary F.& Langabeer, Stephen E.. 2013. Rapid Evolution to Blast Crisis Associated with a Q252H ABL1 Kinase Domain Mutation in e19a2 BCR-ABL1 Chronic Myeloid Leukaemia. Case Reports in Hematology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-475803
Modern Language Association (MLA)
McCarron, Sarah L.…[et al.]. Rapid Evolution to Blast Crisis Associated with a Q252H ABL1 Kinase Domain Mutation in e19a2 BCR-ABL1 Chronic Myeloid Leukaemia. Case Reports in Hematology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-475803
American Medical Association (AMA)
McCarron, Sarah L.& Maher, Karena& Kelly, Johanna& Ryan, Mary F.& Langabeer, Stephen E.. Rapid Evolution to Blast Crisis Associated with a Q252H ABL1 Kinase Domain Mutation in e19a2 BCR-ABL1 Chronic Myeloid Leukaemia. Case Reports in Hematology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-475803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475803