Aqueous Extract from Pepino (Solanum muricatum Ait.) Attenuated Hyperlipidemia and Cardiac Oxidative Stress in Diabetic Mice
Joint Authors
Yin, Mei-chin
Hsu, Cheng-chin
Wang, Zhi-hong
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Nutrition & Dietetics
Medicine
Abstract EN
This study examined the lipid-lowering and cardiac protective effects of aqueous extract of pepino (Solanum muricatum Ait.) in type 2 diabetic mice.
Pepino at 1, 2, or 5% was supplied for 8 weeks.
Results showed that pepino significantly decreased water intake and epididymal fat pad weight in diabetic mice (P<0.05).
Pepino treatments also significantly reduced plasma glucose and insulin levels, HOMA-IR index, and improved oral glucose tolerance (P<0.05).
Plasma and hepatic levels of triglyceride and total cholesterol (TC) were higher in diabetic groups when compared with normal group (P<0.05), pepino treatments at 2 and 5% decreased triglyceride and TC levels in both plasma and liver (P<0.05).
Diabetes enhanced mRNA expression of resistin and diacylglycerol acyltransferase1 (DGAT1) in epididymal fat pad (P<0.05); however, pepino intake significantly suppressed mRNA expression of resistin and DGAT1 in epididymal fat pad (P<0.05).
Pepino intake significantly reduced reactive oxygen species level, increased glutathione level, and retained glutathione peroxidase and catalase activities in cardiac tissues (P<0.05).
These findings suggest that pepino could be considered as a functional food for the alleviation of type 2 diabetes.
American Psychological Association (APA)
Wang, Zhi-hong& Hsu, Cheng-chin& Yin, Mei-chin. 2012. Aqueous Extract from Pepino (Solanum muricatum Ait.) Attenuated Hyperlipidemia and Cardiac Oxidative Stress in Diabetic Mice. ISRN Obesity،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-475815
Modern Language Association (MLA)
Wang, Zhi-hong…[et al.]. Aqueous Extract from Pepino (Solanum muricatum Ait.) Attenuated Hyperlipidemia and Cardiac Oxidative Stress in Diabetic Mice. ISRN Obesity No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-475815
American Medical Association (AMA)
Wang, Zhi-hong& Hsu, Cheng-chin& Yin, Mei-chin. Aqueous Extract from Pepino (Solanum muricatum Ait.) Attenuated Hyperlipidemia and Cardiac Oxidative Stress in Diabetic Mice. ISRN Obesity. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-475815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475815