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Production of Toxic Volatile Trimethylbismuth by the Intestinal Microbiota of Mice
Joint Authors
Bialek, Beatrix
Huber, Britta
Kirsch, Petra
Krüger, Christine
Diaz-Bone, Roland A.
Hensel, Reinhard
Dammann, Philip
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
The biotransformation of metals and metalloids into their volatile methylated derivatives by microbes growing under anaerobic conditions (e.g., the mammalian intestinal microbiota) plays an important role in spreading these compounds in the environment.
In this paper, we could show that the presence of an intact intestinal microbiota of mice provides the conditio sine qua non for the production of these mostly toxic derivatives.
To document the indispensible role of the intestinal microbiota in methylating metals and metalloids to volatile derivatives under in vivo conditions, we compared the methylation capability of conventionally raised (CONV) and germ-free (GF) B6-mice fed with chow containing colloidal bismuth subcitrate (CBS) as the starting material for the formation of volatile methylated metal(loid)s.
Permethylated volatile trimethylbismuth ((CH3)3Bi) was only detected in the blood of the conventionally raised mice.
Concomitantly, a higher bismuth concentration was found in organs such as liver, lung, testicles, and brain of the CONV mice as compared to those of GF mice (P>0.01), strongly suggesting a correlation between the intestinal biomethylation of bismuth and its accumulation in mammalian tissues.
American Psychological Association (APA)
Huber, Britta& Dammann, Philip& Krüger, Christine& Kirsch, Petra& Bialek, Beatrix& Diaz-Bone, Roland A.…[et al.]. 2011. Production of Toxic Volatile Trimethylbismuth by the Intestinal Microbiota of Mice. Journal of Toxicology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-475828
Modern Language Association (MLA)
Huber, Britta…[et al.]. Production of Toxic Volatile Trimethylbismuth by the Intestinal Microbiota of Mice. Journal of Toxicology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-475828
American Medical Association (AMA)
Huber, Britta& Dammann, Philip& Krüger, Christine& Kirsch, Petra& Bialek, Beatrix& Diaz-Bone, Roland A.…[et al.]. Production of Toxic Volatile Trimethylbismuth by the Intestinal Microbiota of Mice. Journal of Toxicology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-475828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475828