Synthesis, Characterization, and In Vitro Anticancer Evaluation of Novel 2,5-Disubstituted 1,3,4-Oxadiazole Analogue
Joint Authors
Shaharyar, Mohammad
Mazumder, Avijit
Salahuddin,
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-07
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
In this series, we have synthesised a new 2,5-disubstituted 1,3,4-oxadiazole in search of potential therapeutics for cancer.
The anticancer activities were evaluated on a panel of 60 cell lines by the National Cancer Institute according to its own screening protocol.
Out of the 24 compounds, 11 were selected and evaluated via single high dose (10−5 M).
In the next phase, two compounds have been selected for five-dose assay.
The compounds 3-(5-benzyl-1,3,4-oxadiazol-2-yl)quinolin-2(1H)-one 18 (NSC-776965) and 3-[5-(2-phenoxymethyl-benzoimidazol-1-ylmethyl)-[1,3,4]oxadiazol-2-yl]-2-p-tolyloxy-quinoline 27 (NSC-776971) showed mean growth percentage of 66.23 and 46.61, respectively, in one-dose assay and their GI50 values ranging between 1.41–15.8 μM and 0.40–14.9 μM, respectively, in 5-dose assay.
American Psychological Association (APA)
Salahuddin, & Mazumder, Avijit& Shaharyar, Mohammad. 2014. Synthesis, Characterization, and In Vitro Anticancer Evaluation of Novel 2,5-Disubstituted 1,3,4-Oxadiazole Analogue. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-475861
Modern Language Association (MLA)
Salahuddin,…[et al.]. Synthesis, Characterization, and In Vitro Anticancer Evaluation of Novel 2,5-Disubstituted 1,3,4-Oxadiazole Analogue. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-475861
American Medical Association (AMA)
Salahuddin, & Mazumder, Avijit& Shaharyar, Mohammad. Synthesis, Characterization, and In Vitro Anticancer Evaluation of Novel 2,5-Disubstituted 1,3,4-Oxadiazole Analogue. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-475861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475861