Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair
Joint Authors
Guerra, Joana
Serrano, Antonio L.
Kharraz, Yacine
Mann, Christopher J.
Muñoz-Cánoves, Pura
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Effective repair of damaged tissues and organs requires the coordinated action of several cell types, including infiltrating inflammatory cells and resident cells.
Recent findings have uncovered a central role for macrophages in the repair of skeletal muscle after acute damage.
If damage persists, as in skeletal muscle pathologies such as Duchenne muscular dystrophy (DMD), macrophage infiltration perpetuates and leads to progressive fibrosis, thus exacerbating disease severity.
Here we discuss how dynamic changes in macrophage populations and activation states in the damaged muscle tissue contribute to its efficient regeneration.
We describe how ordered changes in macrophage polarization, from M1 to M2 subtypes, can differently affect muscle stem cell (satellite cell) functions.
Finally, we also highlight some of the new mechanisms underlying macrophage plasticity and briefly discuss the emerging implications of lymphocytes and other inflammatory cell types in normal versus pathological muscle repair.
American Psychological Association (APA)
Kharraz, Yacine& Guerra, Joana& Mann, Christopher J.& Serrano, Antonio L.& Muñoz-Cánoves, Pura. 2013. Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-475862
Modern Language Association (MLA)
Kharraz, Yacine…[et al.]. Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-475862
American Medical Association (AMA)
Kharraz, Yacine& Guerra, Joana& Mann, Christopher J.& Serrano, Antonio L.& Muñoz-Cánoves, Pura. Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-475862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475862