Insight into Glutamate Excitotoxicity from Synaptic Zinc Homeostasis

Author

Takeda, Atsushi

Source

International Journal of Alzheimer's Disease

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-12-20

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases
Medicine

Abstract EN

Zinc is released from glutamatergic (zincergic) neuron terminals in the hippocampus, followed by the increase in Zn2+ concentration in the intracellular (cytosol) compartment, as well as that in the extracellular compartment.

The increase in Zn2+ concentration in the intracellular compartment during synaptic excitation is mainly due to Zn2+ influx through calcium-permeable channels and serves as Zn2+ signaling as well as the case in the extracellular compartment.

Synaptic Zn2+ homeostasis is important for glutamate signaling and altered under numerous pathological processes such as Alzheimer's disease.

Synaptic Zn2+ homeostasis might be altered in old age, and this alteration might be involved in the pathogenesis and progression of Alzheimer's disease; Zinc may play as a key-mediating factor in the pathophysiology of Alzheimer's disease.

This paper summarizes the role of Zn2+ signaling in glutamate excitotoxicity, which is involved in Alzheimer's disease, to understand the significance of synaptic Zn2+ homeostasis in the pathophysiology of Alzheimer's disease.

American Psychological Association (APA)

Takeda, Atsushi. 2010. Insight into Glutamate Excitotoxicity from Synaptic Zinc Homeostasis. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-475868

Modern Language Association (MLA)

Takeda, Atsushi. Insight into Glutamate Excitotoxicity from Synaptic Zinc Homeostasis. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-475868

American Medical Association (AMA)

Takeda, Atsushi. Insight into Glutamate Excitotoxicity from Synaptic Zinc Homeostasis. International Journal of Alzheimer's Disease. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-475868

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-475868