Possible Involvement of a Mitochondrial Translation Initiation Factor 3 Variant Causing Decreased mRNA Levels in Parkinson's Disease
Joint Authors
Håkansson, Anna
Belin, Andrea Carmine
Westerlund, Marie
Ran, Caroline
Nissbrandt, Hans
Galter, Dagmar
Sydow, Olof
Lind, Charlotta
Anvret, Anna
Thelander, Ann-Christin
Source
Comparative and Functional Genomics
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Genes important for mitochondrial function have been implicated in Parkinson's disease (PD).
Mitochondrial translation initiation factor 3 (MTIF3) is a nuclear encoded protein required for the initiation of complex formation on mitochondrial ribosomes.
Dysfunction of MTIF3 may impair mitochondrial function and dopamine neurons appear to be particularly vulnerable to oxidative stress, which may relate to their degeneration in PD.
An association was recently reported between the synonymous rs7669(C>T) in MTIF3 and PD in a German case-control material.
We investigated rs7669 in a Swedish Parkinson case-control material.
The study revealed no significant association of the individual genotypes or alleles with PD.
When comparing the combined TT/CT-genotypes versus the CC-genotype, we observed a significant association (P=.0473) with PD.
We also demonstrated that the TT-genotype causes a significant decrease in MTIF3 mRNA expression compared to the CC-genotype (P=.0163).
Our findings support the hypothesis that MTIF3 may be involved in the etiology of PD.
American Psychological Association (APA)
Anvret, Anna& Ran, Caroline& Westerlund, Marie& Thelander, Ann-Christin& Sydow, Olof& Lind, Charlotta…[et al.]. 2010. Possible Involvement of a Mitochondrial Translation Initiation Factor 3 Variant Causing Decreased mRNA Levels in Parkinson's Disease. Comparative and Functional Genomics،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-475888
Modern Language Association (MLA)
Anvret, Anna…[et al.]. Possible Involvement of a Mitochondrial Translation Initiation Factor 3 Variant Causing Decreased mRNA Levels in Parkinson's Disease. Comparative and Functional Genomics No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-475888
American Medical Association (AMA)
Anvret, Anna& Ran, Caroline& Westerlund, Marie& Thelander, Ann-Christin& Sydow, Olof& Lind, Charlotta…[et al.]. Possible Involvement of a Mitochondrial Translation Initiation Factor 3 Variant Causing Decreased mRNA Levels in Parkinson's Disease. Comparative and Functional Genomics. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-475888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475888