Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals
Joint Authors
Westbrook, Aya
Taylor, Robert T.
Hankinson, Oliver
Chen, Natalie
Zhang, Ruixue
Hsu, Erin L.
Wang, Feng
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-03-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
CXCR4 is a chemokine receptor frequently overexpressed on primary tumor cells.
Organs to which these cancers metastasize secrete CXCL12, the unique ligand for CXCR4, which stimulates invasion and metastasis to these sites.
Similar to our previous work with the chemoprotective phytochemical, 3,3′-diindolylmethane (DIM), we show here that genistein also downregulates CXCR4 and CXCL12 and subsequently lowers the migratory and invasive potentials of breast and ovarian cancer cells.
Moreover, genistein and DIM elicit a significantly greater cumulative effect in lowering CXCR4 and CXCL12 levels than either compound alone.
Our data suggest a novel mechanism for the protective effects of phytochemicals against cancer progression and indicate that in combination, these compounds may prove even more efficacious.
American Psychological Association (APA)
Hsu, Erin L.& Chen, Natalie& Westbrook, Aya& Wang, Feng& Zhang, Ruixue& Taylor, Robert T.…[et al.]. 2009. Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals. Journal of Oncology،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-475912
Modern Language Association (MLA)
Hsu, Erin L.…[et al.]. Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals. Journal of Oncology No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-475912
American Medical Association (AMA)
Hsu, Erin L.& Chen, Natalie& Westbrook, Aya& Wang, Feng& Zhang, Ruixue& Taylor, Robert T.…[et al.]. Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals. Journal of Oncology. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-475912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475912