Localization of Magic-F1 Transgene, Involved in Muscular Hypertrophy, during Early Myogenesis
Joint Authors
Tribioli, Carla
Bongio, Matilde
Magenes, Giovanni
Ronzoni, Flavio
Sampaolesi, Maurilio
Cusella De Angelis, Maria Gabriella
Conte, Silvio
Bellazzi, Riccardo
Galli, Daniela
Vercesi, Luigi
Cassano, Marco
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We recently showed that Magic-F1 (Met-activating genetically improved chimeric factor 1), a human recombinant protein derived from hepatocyte growth factor/scatter factor (HGF/SF) induces muscle cell hypertrophy but not progenitor cell proliferation, both in vitro and in vivo.
Here, we examined the temporal and spatial expression pattern of Magic-F1 in comparison with Pax3 (paired box gene 3) transcription factor during embryogenesis.
Ranging from 9.5 to 17.5 dpc (days post coitum) mouse embryos were analyzed by in situ hybridization using whole mounts during early stages of development (9.5–10.5–11.5 dpc) and cryostat sections for later stages (11.5–13.5–15.5–17.5 dpc).
We found that Magic-F1 is expressed in developing organs and tissues of mesenchymal origin, where Pax3 signal appears to be downregulated respect to the wt embryos.
These data suggest that Magic-F1 could be responsible of muscular hypertrophy, cooperating with Pax3 signal pathway in skeletal muscle precursor cells.
American Psychological Association (APA)
Ronzoni, Flavio& Bongio, Matilde& Conte, Silvio& Vercesi, Luigi& Cassano, Marco& Tribioli, Carla…[et al.]. 2011. Localization of Magic-F1 Transgene, Involved in Muscular Hypertrophy, during Early Myogenesis. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-475923
Modern Language Association (MLA)
Ronzoni, Flavio…[et al.]. Localization of Magic-F1 Transgene, Involved in Muscular Hypertrophy, during Early Myogenesis. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-475923
American Medical Association (AMA)
Ronzoni, Flavio& Bongio, Matilde& Conte, Silvio& Vercesi, Luigi& Cassano, Marco& Tribioli, Carla…[et al.]. Localization of Magic-F1 Transgene, Involved in Muscular Hypertrophy, during Early Myogenesis. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-475923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475923