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Development of Mucosal Immunity in Children : A Rationale for Sublingual Immunotherapy?
Author
Szczawinska-Poplonyk, Aleksandra
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The mucosal immune system has bidirectional tasks to mount an effective defense against invading harmful pathogens and to suppress the immune response to alimentary antigens and commensal bacterial flora.
Oral tolerance is a suppression of the mucosal immune pathway related to a specific immunophenotype of the dendritic cells and an induction of the regulatory T cells as well as with the silencing of the effector T cell response by anergy and deletion.
The physiological dynamic process of the anatomical and functional maturation of the immune system occurring in children during pre- and postnatal periods is a significant factor, having an impact on the fine balance between the activation and the suppression of the immune response.
In this paper, mechanisms of mucosal immunity and tolerance induction in terms of maturational issues are discussed with a special emphasis on the implications for a novel therapeutic intervention in allergic diseases via the sublingual route.
American Psychological Association (APA)
Szczawinska-Poplonyk, Aleksandra. 2011. Development of Mucosal Immunity in Children : A Rationale for Sublingual Immunotherapy?. Journal of Allergy،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-475994
Modern Language Association (MLA)
Szczawinska-Poplonyk, Aleksandra. Development of Mucosal Immunity in Children : A Rationale for Sublingual Immunotherapy?. Journal of Allergy No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-475994
American Medical Association (AMA)
Szczawinska-Poplonyk, Aleksandra. Development of Mucosal Immunity in Children : A Rationale for Sublingual Immunotherapy?. Journal of Allergy. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-475994
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475994