Patterns of Use and Outcomes in Patients Treated with Etravirine in the HIV Research Network

Abstract EN

This observational analysis examined the clinical outcomes of patients receiving etravirine-(ETR-) based therapy, particularly with protease inhibitors (PIs) other than darunavir (DRV) and with raltegravir (RAL).

Data included treatment-experienced adults in the HIV Research Network who began ETR-containing antiretroviral regimens in 2008–2010.

The primary objective was to assess 6-month outcomes (durability, i.e., still on an ETR-containing regimen; change in CD4+ cell count and HIV-1 RNA <400 copies/mL).

The cohort included 587 patients receiving ETR; 42% of ETR use was in patients not on DRV/ritonavir (r).

Patients receiving ETR plus DRV/r had longer durability versus those on ETR plus a PI other than DRV/r at months 6 (91.2% versus 85.5%) and 12 (77.4% versus 65.2%), respectively.

Patients on regimens with a PI other than DRV/r were the least likely to be receiving ETR at month 6 (85.5%) versus patients on other ETR-based regimens.

Patients on regimens without a PI and without RAL had lower virologic suppression (month 6, 54.2%; month 12, 63.2%) versus patients on other ETR-based regimens.

In a clinical care, nontrial setting, ETR was used in regimens without DRV/r.

In this population, the 6-month response rates were similar and durable across all regimens, except when ETR was used without RAL and without a PI.