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XRCC1 Arg399Gln and Arg194Trp Polymorphisms and Risk of Systemic Lupus Erythematosus in an Iranian Population : A Pilot Study
Joint Authors
Naghavi, Anoosh
Mohammadoo-khorasani, Milad
Sandoughi, Mahnaz
Tabatabai, Ehsan
Salimi, Saeedeh
Zakeri, Zahra
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Evidences are suggesting that DNA damage is implicated in development of systemic lupus erythematosus (SLE).
Therefore we focused on two common XRCC1 polymorphisms (Arg399Gln and Arg194Trp) in SLE susceptibility in South East of Iran.
Methods.
Peripheral blood DNA was extracted from 163 SLE patients and 180 healthy controls.
PCR-restriction fragment length polymorphism method was used for genotyping of XRCC1 Arg399Gln and Arg194Trp polymorphisms.
Results.
The frequency of Arg/Gln genotype of the XRCC1 Arg399Gln polymorphism was significantly lower in SLE patients than controls.
Moreover, lower frequency of Arg/Gln genotype was found in SLE patients with malar rash compared to patients without this manifestation.
No association was observed between XRCC1 Arg194Trp polymorphism and increased risk of SLE in studied population.
Haplotype analysis revealed no correlation between four haplotypes of XRCC1 Arg399Gln and Arg194Trp polymorphisms and SLE risk.
Conclusion.
These findings suggest that XRCC1 399 Arg/Gln heterozygous genotype plays a protective role in SLE susceptibility.
American Psychological Association (APA)
Salimi, Saeedeh& Mohammadoo-khorasani, Milad& Tabatabai, Ehsan& Sandoughi, Mahnaz& Zakeri, Zahra& Naghavi, Anoosh. 2014. XRCC1 Arg399Gln and Arg194Trp Polymorphisms and Risk of Systemic Lupus Erythematosus in an Iranian Population : A Pilot Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-476016
Modern Language Association (MLA)
Salimi, Saeedeh…[et al.]. XRCC1 Arg399Gln and Arg194Trp Polymorphisms and Risk of Systemic Lupus Erythematosus in an Iranian Population : A Pilot Study. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-476016
American Medical Association (AMA)
Salimi, Saeedeh& Mohammadoo-khorasani, Milad& Tabatabai, Ehsan& Sandoughi, Mahnaz& Zakeri, Zahra& Naghavi, Anoosh. XRCC1 Arg399Gln and Arg194Trp Polymorphisms and Risk of Systemic Lupus Erythematosus in an Iranian Population : A Pilot Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-476016
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476016