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Gastroprotective Effects of Lion’s Mane Mushroom Hericium erinaceus (Bull. : Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats
Joint Authors
Raman, Jegadeesh
Abdulla, Mahmood Ameen
Phan, Chia-Wei
Kuppusamy, Umah Rani
Sabaratnam, Vikineswary
Golbabapour, Shahram
Wong, Jing-Yang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hericium erinaceus is a famous tonic in oriental medicine.
The gastroprotective effects of aqueous extract of H.
erinaceus against ethanol-induced ulcers in Sprague Dawley rats were investigated.
The possible involvements of lipid peroxidation, superoxide dismutase, and catalase were also investigated.
Acute toxicity study was performed.
The effects of aqueous extract of H.
erinaceus on the ulcer areas, ulcer inhibition, gastric wall mucus, gross and histological gastric lesions, antioxidant levels, and malondialdehyde (MDA) contents were evaluated in ethanol-induced ulcer in vivo.
In acute toxicity study, a high dose of 5 g/kg did not manifest any toxicological signs in rats.
The extract promoted ulcer protection as ascertained by a significant reduction of the ulcer area.
Furthermore, it exhibited a significant protection activity against gastric mucosal injury by preventing the depletion of antioxidant enzymes.
The level of MDA was also limited in rat stomach tissues when compared with the ulcer control group.
Immunohistochemistry showed upregulation of HSP70 protein and downregulation of BAX protein in rats pretreated with the extract.
The aqueous extract of H.
erinaceus protected gastric mucosa in our in vivo model.
It is speculated that the bioactive compounds present in the extract may play a major role in gastroprotective activity.
American Psychological Association (APA)
Wong, Jing-Yang& Abdulla, Mahmood Ameen& Raman, Jegadeesh& Phan, Chia-Wei& Kuppusamy, Umah Rani& Golbabapour, Shahram…[et al.]. 2013. Gastroprotective Effects of Lion’s Mane Mushroom Hericium erinaceus (Bull. : Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-476019
Modern Language Association (MLA)
Wong, Jing-Yang…[et al.]. Gastroprotective Effects of Lion’s Mane Mushroom Hericium erinaceus (Bull. : Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-476019
American Medical Association (AMA)
Wong, Jing-Yang& Abdulla, Mahmood Ameen& Raman, Jegadeesh& Phan, Chia-Wei& Kuppusamy, Umah Rani& Golbabapour, Shahram…[et al.]. Gastroprotective Effects of Lion’s Mane Mushroom Hericium erinaceus (Bull. : Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-476019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476019