Angiotensin-(1-7)-Mediated Signaling in Cardiomyocytes
Joint Authors
Gomes, Enéas R. M.
Souza dos Santos, Robson Augusto
Guatimosim, Silvia
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The Renin-Angiotensin System (RAS) acts at multiple targets and has its synthesis machinery present in different tissues, including the heart.
Actually, it is well known that besides Ang II, the RAS has other active peptides.
Of particular interest is the heptapeptide Ang-(1-7) that has been shown to exert cardioprotective effects.
In this way, great compilations about Ang-(1-7) actions in the heart have been presented in the literature.
However, much less information is available concerning the Ang-(1-7) actions directly in cardiomyocytes.
In this paper, we show the actual knowledge about Ang-(1-7)-mediated signaling in cardiac cells more specifically we provide a brief overview of ACE2/Ang-(1-7)/Mas axis; and highlight the discoveries made in cardiomyocyte physiology through the use of genetic approaches.
Finally, we discuss the protective signaling induced by Ang-(1-7) in cardiomyocytes and point molecular determinants of these effects.
American Psychological Association (APA)
Gomes, Enéas R. M.& Souza dos Santos, Robson Augusto& Guatimosim, Silvia. 2012. Angiotensin-(1-7)-Mediated Signaling in Cardiomyocytes. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-476029
Modern Language Association (MLA)
Gomes, Enéas R. M.…[et al.]. Angiotensin-(1-7)-Mediated Signaling in Cardiomyocytes. International Journal of Hypertension No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-476029
American Medical Association (AMA)
Gomes, Enéas R. M.& Souza dos Santos, Robson Augusto& Guatimosim, Silvia. Angiotensin-(1-7)-Mediated Signaling in Cardiomyocytes. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-476029
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476029