Role of Mitochondria in HIV Infection and Associated Metabolic Disorders : Focus on Nonalcoholic Fatty Liver Disease and Lipodystrophy Syndrome
Joint Authors
Pérez-Martínez, L.
Pérez-Matute, P.
Blanco, J. R.
Oteo, J. A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Highly active antiretroviral therapy (HAART) has considerably improved the prognosis of HIV-infected patients.
However, prolonged use of HAART has been related to long-term adverse events that can compromise patient health such as HIV-associated lipodystrophy syndrome (HALS) and nonalcoholic fatty liver disease (NAFLD).
There is consistent evidence for a central role of mitochondrial dysfunction in these pathologies.
Nucleotide reverse transcriptase inhibitors (NRTIs) have been described to be mainly responsible for mitochondrial dysfunction in adipose tissue and liver although nonnucleoside transcriptase inhibitors (NNRTIs) or protease inhibitors (PIs) have also showed mitochondrial toxicity, which is a major concern for the selection and the long-term adherence to a particular therapy.
Several mechanisms explain these deleterious effects of HAART on mitochondria, and evidence points to other mechanisms beyond the “Pol-γ hypothesis.” HIV infection has also direct effects on mitochondria.
In addition to the negative effects described for HIV itself and/or HAART on mitochondria, HIV-infected patients are more prone to develop a premature aging and, therefore, to present an increased oxidative state that could lead to the development of these metabolic disturbances observed in HIV-infected patients.
American Psychological Association (APA)
Pérez-Matute, P.& Pérez-Martínez, L.& Blanco, J. R.& Oteo, J. A.. 2013. Role of Mitochondria in HIV Infection and Associated Metabolic Disorders : Focus on Nonalcoholic Fatty Liver Disease and Lipodystrophy Syndrome. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-476050
Modern Language Association (MLA)
Pérez-Matute, P.…[et al.]. Role of Mitochondria in HIV Infection and Associated Metabolic Disorders : Focus on Nonalcoholic Fatty Liver Disease and Lipodystrophy Syndrome. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-476050
American Medical Association (AMA)
Pérez-Matute, P.& Pérez-Martínez, L.& Blanco, J. R.& Oteo, J. A.. Role of Mitochondria in HIV Infection and Associated Metabolic Disorders : Focus on Nonalcoholic Fatty Liver Disease and Lipodystrophy Syndrome. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-476050
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476050