Optimization of Synthesis of Seleno-Sargassum fusiforme (Harv.) Setch. Polysaccharide by Response Surface Methodology, Its Characterization, and Antioxidant Activity
Joint Authors
Ji, Yu-Bin
Dong, Fang
Yu, Miao
Qin, Long
Liu, Dan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The response surface methodology was employed to optimize the synthesis conditions of seleno-Sargassum fusiforme (Harv.) Setch.
polysaccharide.
Three independent variables (reaction time, reaction temperature, and ratio of Na2SeO3 to SFPSI) were tested.
Furthermore, the characterization and antioxidant activity of Se-SFPSI in vivo were investigated.
The result showed that the actual experimental Se content of Se-SFPSI was 3.352 mg/g at the optimum reaction conditions of reaction time 8 h, reaction temperature 71°C, and ratio of Na2SeO3 to SFPSIB 1.0 g/g.
A series of experiments showed that the characterization of Se-SFPSIB was significantly different from that of SFPSIB.
Additionally, antioxidant activity assay indicated that the Se-SFPSIB could increase catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activity of mice bearing tumor S180 in blood, heart, and liver while decreasing malondialdehyde (MDA) levels.
It can be concluded that selenylation is a feasible approach to obtain seleno-polysaccharide which was utilized as highly biological medicine or functional food.
American Psychological Association (APA)
Ji, Yu-Bin& Dong, Fang& Yu, Miao& Qin, Long& Liu, Dan. 2013. Optimization of Synthesis of Seleno-Sargassum fusiforme (Harv.) Setch. Polysaccharide by Response Surface Methodology, Its Characterization, and Antioxidant Activity. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-476063
Modern Language Association (MLA)
Ji, Yu-Bin…[et al.]. Optimization of Synthesis of Seleno-Sargassum fusiforme (Harv.) Setch. Polysaccharide by Response Surface Methodology, Its Characterization, and Antioxidant Activity. Journal of Chemistry No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-476063
American Medical Association (AMA)
Ji, Yu-Bin& Dong, Fang& Yu, Miao& Qin, Long& Liu, Dan. Optimization of Synthesis of Seleno-Sargassum fusiforme (Harv.) Setch. Polysaccharide by Response Surface Methodology, Its Characterization, and Antioxidant Activity. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-476063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476063