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Healing Efficacy of an EGF Impregnated Triple Gel Based Wound Dressing : In Vitro and In Vivo Studies
Joint Authors
Dinarvand, Rassoul
Talaie, Fatemeh
Khanbanha, Najmeh
Taheri, Azade
Mahbod, Mirgholamreza
Atyabi, Fatemeh
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
To accomplish an ideal wound healing process which promotes healthy tissue growth with less scaring, a novel gel based topical drug delivery system composed of 3 different polymers chitosan, dextran sulfate, and polyvinylpyrrolidone K30 (CDP) was prepared.
The physicochemical properties of the prepared gels were investigated in vitro.
Gels showed a maximum swelling ratio of 50 ± 1.95 times of dried gel in PBS at pH 7.4.
The swelling ratios increase in acidic and alkaline pH to 55.3 ± 1.75 and 65.5 ± 2.42, respectively.
In the rheological test, prepared gels revealed viscoelastic properties and a small linear viscoelastic region of 0.166%.
In vivo wound healing promoting activities of CDP gels containing 20 μg/mL EGF were evaluated on surgically induced dermal wounds in rats using pathologic examination.
The application of CDP gel with incorporated EGF significantly reduced the defect on the rat’s skin and enhanced epithelial healing compared with the topical application of the EGF-free CDP gel.
The results clearly substantiate the beneficial effects of the topical application of CDP containing EGF in the acceleration of healthy wound healing process with less scarring.
American Psychological Association (APA)
Khanbanha, Najmeh& Atyabi, Fatemeh& Taheri, Azade& Talaie, Fatemeh& Mahbod, Mirgholamreza& Dinarvand, Rassoul. 2014. Healing Efficacy of an EGF Impregnated Triple Gel Based Wound Dressing : In Vitro and In Vivo Studies. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-476085
Modern Language Association (MLA)
Khanbanha, Najmeh…[et al.]. Healing Efficacy of an EGF Impregnated Triple Gel Based Wound Dressing : In Vitro and In Vivo Studies. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-476085
American Medical Association (AMA)
Khanbanha, Najmeh& Atyabi, Fatemeh& Taheri, Azade& Talaie, Fatemeh& Mahbod, Mirgholamreza& Dinarvand, Rassoul. Healing Efficacy of an EGF Impregnated Triple Gel Based Wound Dressing : In Vitro and In Vivo Studies. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-476085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476085