Invasive Aspergillosis in a Renal Transplant Recipient Successfully Treated with Interferon-Gamma
Joint Authors
Chirch, L. M.
Seidman, R.
Desai, A. G.
Estrada, Chelsea
Suh, H.
Darras, F.
Nord, Edward P.
Source
Case Reports in Transplantation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Invasive aspergillosis is a serious complication of solid organ transplantation.
An early diagnosis is hampered by the lack of reliable serum markers and, even if appropriately diagnosed and treated with current antifungal agents, has a high mortality rate.
We report a case of invasive pulmonary and cerebral aspergillosis in a renal transplant patient treated with IFN-γ in conjunction with combination anti-fungal therapy for six weeks in whom complete resolution of the fungal infection was achieved.
Renal function remained intact throughout the treatment period.
Surveillance CT scans of the chest and head showed resolution of prior disease but revealed a new left upper lobe mass four months after completion of treatment with IFN-γ.
Biopsy of the lesion was positive for primary lung adenocarcinoma, for which she underwent left upper lobe resection.
The pathology report confirmed clear surgical margins and lymph nodes and no evidence of fungal hyphae.
IFN-γ should be considered early in the management of invasive aspergillosis in renal transplant patients.
To date, allograft rejection has not been encountered.
American Psychological Association (APA)
Estrada, Chelsea& Desai, A. G.& Chirch, L. M.& Suh, H.& Seidman, R.& Darras, F.…[et al.]. 2012. Invasive Aspergillosis in a Renal Transplant Recipient Successfully Treated with Interferon-Gamma. Case Reports in Transplantation،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-476090
Modern Language Association (MLA)
Estrada, Chelsea…[et al.]. Invasive Aspergillosis in a Renal Transplant Recipient Successfully Treated with Interferon-Gamma. Case Reports in Transplantation No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-476090
American Medical Association (AMA)
Estrada, Chelsea& Desai, A. G.& Chirch, L. M.& Suh, H.& Seidman, R.& Darras, F.…[et al.]. Invasive Aspergillosis in a Renal Transplant Recipient Successfully Treated with Interferon-Gamma. Case Reports in Transplantation. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-476090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476090