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In Vitro and In Vivo Anticancer Effects of Sterol Fraction from Red Algae Porphyra dentata
Joint Authors
Kazłowska, Katarzyna
Lin, Hong-Ting Victor
Tsai, Guo-Jane
Chang, Shun-Hsien
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Porphyra dentata, an edible red macroalgae, is used as a folk medicine in Asia.
This study evaluated in vitro and in vivo the protective effect of a sterol fraction from P.
dentata against breast cancer linked to tumor-induced myeloid derived-suppressor cells (MDSCs).
A sterol fraction containing cholesterol, β-sitosterol, and campesterol was prepared by solvent fractionation of methanol extract of P.
dentata in silica gel column chromatography.
This sterol fraction in vitro significantly inhibited cell growth and induced apoptosis in 4T1 cancer cells.
Intraperitoneal injection of this sterol fraction at 10 and 25 mg/kg body weight into 4T1 cell-implanted tumor BALB/c mice significantly inhibited the growth of tumor nodules and increased the survival rate of mice.
This sterol fraction significantly decreased the reactive oxygen species (ROS) and arginase activity of MDSCs in tumor-bearing mice.
Therefore, the sterol fraction from P.
dentata showed potential for protecting an organism from 4T1 cell-based tumor genesis.
American Psychological Association (APA)
Kazłowska, Katarzyna& Lin, Hong-Ting Victor& Chang, Shun-Hsien& Tsai, Guo-Jane. 2013. In Vitro and In Vivo Anticancer Effects of Sterol Fraction from Red Algae Porphyra dentata. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-476106
Modern Language Association (MLA)
Kazłowska, Katarzyna…[et al.]. In Vitro and In Vivo Anticancer Effects of Sterol Fraction from Red Algae Porphyra dentata. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-476106
American Medical Association (AMA)
Kazłowska, Katarzyna& Lin, Hong-Ting Victor& Chang, Shun-Hsien& Tsai, Guo-Jane. In Vitro and In Vivo Anticancer Effects of Sterol Fraction from Red Algae Porphyra dentata. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-476106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476106